The U.S. President’s Malaria Initiative (PMI) and Madagascar joined forces in 2008 to combat malaria. U.S. investments contributed to substantial reductions in Madagascar’s malaria cases, but the country’s 2009 political crisis disrupted these efforts and a resurgence in malaria followed. Malaria is one of the leading causes of death among children under five in Madagascar and severe malaria is among the top five causes of overall deaths in the country. Today, PMI is working in close coordination with Madagascar’s government to reclaim previous gains against the disease. They’re laser-focused on improving and expanding Madagascar’s national health information system, equipping community health workers with real-time data through smartphone apps, and administering millions of rapid diagnostic tests and malaria treatments to Malagasy communities during the COVID-19 pandemic.